Standard profile should set sensible performance defaults, this would be a good one to change, as well as setting max_age and possibly internal caching.
The only point against this is if you run into trouble with CSS/JS aggregation because you're trying to change a file or similar. However then you'll have to go switch it off and you'll learn what it is if you didn't already.
This seems like a good trade-off compared to sites launching without it because it never came up.