How to make changes workable that are done in hook menu without clearing cached data?

Any change in the hook menu will not work until cache will be cleared by going to Admin-> performance -> clear cached data.
I have a custom module and i removed access arguments and add access callback to one of the menu item of hook_menu but it will not work until i clear cache. I have to do this on live site where i don't want to clear cache. Is there any way my change will work without clearing cache?